Dr Ben Sessa, MD’s bio on Twitter describes him as an addictions psychiatrist, MDMA psychotherapist, psychedelic researcher and writer; his website goes into even greater detail the work he’s done in all of these fields and the expertise he’s developed. What I’m getting at is this guy is the real deal.
Last week, Dr Sessa tweeted about the difference between post-festival blues (associated with MDMA use, specifically) and the absence of any noticeable comedown after medical MDMA. He states that using MDMA in conjunction with other substances as well as lack of sleep and excessive exercise are generally what lead to the day-after comedowns.
https://twitter.com/DrSessa/status/1175720822704676864 
While this tweet had its own, discrete purpose, it led into a greater discussion in the replies about how to dose when you do use MDMA in a recreational setting.
According to Dr Sessa, the method that “gives optimal positive mood effects” and is “also safer” is to halve your dose every two hours. Keeping a sustained high dose will “flood the 5-HT 1a & 1b receptors” and he says you might as well just drink coffee at that point.
https://twitter.com/DrSessa/status/1175791711924248576
https://twitter.com/DrSessa/status/1176759306336854016
Follow these tips, and you might just go into the next day feeling refreshed and energized instead of feeling like you’re at death’s door. Of course these are just the recommendations from one physician and everyone’s body is different, so do not take these dosage suggestions as gospel. Additionally, the purity of any one individual’s MDMA will also vary, and should be taken into account.
However, halving the doses every two hours is still an effective method of making sure you have a good night’s rest after all is said and done.
